Brumme explained, “The purpose of our study was to investigate the adaptation of HIV to immune selection pressures in the North American population. To do this, we studied HIV specimens dating back from 1979 to the present day. From these specimens we extracted human immune information as well as virus sequence data and looked for evidence that the virus was adapting to our immune systems over time.”
With funding from the Canadian Institutes of Health Research (CIHR) and the Michael Smith Foundation for Health Research (MSFHR), Brumme’s lab was able to collaborate with scientists at UBC, the BC Centre for Excellence in HIV/AIDS, and sites across the US.
Although HIV-1 specimens used in the study were from 1979, the oldest specimens sequenced date back to 1959 and 1960. “Both are from Central Africa. With respect to North America, the oldest sequences date back to 1979 and were collected as part of our study.” Brumme said.
The findings of the study, she stated, were evidence that the virus is indeed slowly adapting over time to its human hosts. However, Brumme says there is no need to panic: “This change is so gradual that it is unlikely to have an impact on host immunity to HIV — or vaccine design — on a relevant timescale.”
She continued, “Basically, we’ve got the tools now, in the form of potent anti-HIV drugs, to turn the tide of HIV globally. These drugs do two things: a) they save lives and b) they reduce the risk of HIV transmission essentially to zero.”
The research team hopes that by collecting and sequencing historic HIV-1 isolates, they will be able to achieve a deeper understanding of how HIV has spread around the world. “Understanding how HIV evolves in infected persons and host populations is also relevant to HIV prevention, notably development of an HIV vaccine,” Brumme said.
Although the evolutionary side of HIV is just one piece in a much larger puzzle, the team says they have reasons to be hopeful. Brumme explained, “A major global priority is the delivery of HIV treatment to the millions of people worldwide who need it — to save lives and eliminate new infections. While we do the above, we also need to continue to invest resources and scientific efforts towards finding an HIV vaccine and an HIV cure.”
The purpose of our study was to investigate the adaptation of HIV to
immune selection pressures in the North American population.
i was diagnosed with HIV/AIDS for over 5 years which made loose my job and my relationship with my fiance after he discovered that i was having HIV, he departed from me i tried all my best to make him stays with me, but neglected me until a friend of mine on Facebook from Singapore told me Great healer, who will restore my life back with his powerful healing spell, he sent me the email address to contact (dr.aribaspelltemple@outlook.com) and i quickly contacted him, and he said my condition can solved, that he will treat the disease immediately only if i can accept trust him and accept his terms and condition, i Agreed because i was so much in need of help by all means, so i did all he want from me and surprisingly on Sunday last week He sent me a text, that i should hurry up to the hospital for a checkup, which i truly did, i confirm from my doctor that i am now ( HIV NEGATIVE) my eyes filled with tears and joy, crying heavily because truly the disease deprived me of many things from my life, This is a Miracle, Please do not en-devour to email dr.aribaspelltemple@outlook.com, or draribaspelltemple@gmail.com for healing and solution
i was diagnosed with HIV/AIDS for over 5 years which made loose my job and my relationship with my fiance after he discovered that i was having HIV, he departed from me i tried all my best to make him stays with me, but neglected me until a friend of mine on Facebook from Singapore told me Great healer, who will restore my life back with his powerful healing spell, he sent me the email address to contact (dr.aribaspelltemple@outlook.com) and i quickly contacted him, and he said my condition can solved, that he will treat the disease immediately only if i can accept trust him and accept his terms and condition, i Agreed because i was so much in need of help by all means, so i did all he want from me and surprisingly on Sunday last week He sent me a text, that i should hurry up to the hospital for a checkup, which i truly did, i confirm from my doctor that i am now ( HIV NEGATIVE) my eyes filled with tears and joy, crying heavily because truly the disease deprived me of many things from my life, This is a Miracle, Please do not en-devour to email dr.aribaspelltemple@outlook.com, or draribaspelltemple@gmail.com for healing and solution….
its a pleasure for me to write this testimony about this wonderful thing that happened to me last week on how i got my HIV aids cured, i have been reading so-many post of some people who were cured of HIV, but i never believed them, I was hurt and depressed so I was too curious and wanted to try dr.Ariba then i contacted him on his email on dr.aribaspelltemple@outlook.com, when i contact him, he assured me 100% that he will heal me, i pleaded with him to help me out, its a great success that he healed just as he promised, he told me that in three days time that i should go and check on my HIV status, I was floored that when i went to the hospital to check of my status that i was HIV negative, i never thought possible that dr.Ariba can do miracles, i never really believed in magic but I played along with a little hope and and faith and after everything but dr ARIBA changed my life and made me a true believer you can contact him on dr.aribaspelltemple@outlook.com, or draribaspelltemple@gmail.com he can help you out
I never believed that I would ever be cured of HIV on till
now.
Am From USA i saw some testimonies on the internet on how Dr. Ariba cured a
girl of HIV/AIDS. but because i was desperate i tried and contacted him on
dr.aribaspelltemple@outlook.com and luckilly he prepared the cure for me and
sent me a parcel and after two days of drinking the content of the percel as
instructed, i was healed totally. if you need his help, you can contact him on
dr.aribaspelltemple@outlook.com Or draribaspelltemple@gmail.com and
get cured.
Kind regards,
I never believed that I would ever be cured of HIV on till
now.
Am From USA i saw some testimonies on the internet on how Dr. Ariba cured a
girl of HIV/AIDS. but because i was desperate i tried and contacted him on
dr.aribaspelltemple@outlook.com and luckilly he prepared the cure for me and
sent me a parcel and after two days of drinking the content of the percel as
instructed, i was healed totally. if you need his help, you can contact him on
dr.aribaspelltemple@outlook.com Or draribaspelltemple@gmail.com and
get cured.
Kind regards,…………